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Glutathione operates by affecting melanin synthesis on the skin

As we age, glutathione levels decline due to: Environmental pollution UV radiation Stress Poor nutrition Smoking Medical conditions This reduction may contribute to dull skin, pigmentation issues, and visible signs of aging

Despite five decades of research, its receptor and mechanism remain uncharacterised

Indirect calorimetry and metabolic studies Body composition was assessed using an EchoMRI-100 T system (Echo Medical Systems) in multiple cohorts of Gpr146-deficient mice, including whole-body knockout ( Gpr146/ ) and control ( Gpr146/ ) mice (both sexes) fed either chow or high-fat diet (HFD), as well as adipose-specific knockout mice subjected to HFD feeding

The immunoprecipitates were then eluted and treated with proteinase K before RNA extraction utilizing TRIzol